Medicine
Mohsen Nabiuni; Jaber Hatam; Maryam Milanifard; Elham Seidkhani; Amin Jahanbakhshi
Abstract
Peripheral neuropathy is the result of damage to nerves outside the brain and spinal cord and often causes weakness, numbness and pain, usually in the hands and feet. It can also affect other parts and functions of the body such as digestion, urination and blood circulation. The peripheral nervous system ...
Read More
Peripheral neuropathy is the result of damage to nerves outside the brain and spinal cord and often causes weakness, numbness and pain, usually in the hands and feet. It can also affect other parts and functions of the body such as digestion, urination and blood circulation. The peripheral nervous system is responsible for sending information from the brain and spinal cord to other parts of the body. Also, peripheral nerves send sensory information to the central nervous system. Peripheral neuropathy can be caused by severe injuries, infections, metabolic problems, hereditary causes, and exposure to toxic substances, one of the most common causes of which is diabetes. People with peripheral neuropathy usually experience throbbing, burning, or tingling pain, and in many cases, symptoms improve. Especially if the cause is a treatable problem. Medicine can also reduce the pain of peripheral neuropathy. There are different types of peripheral neuropathy caused by different causes. These cases range from carpal tunnel syndrome to nerve damage due to diabetes. All types of peripheral neuropathy as a group are especially common in people over 55 years of age. This condition affects 3-4% of people in this group. Neuropathies are usually categorized based on the problems they cause and their causes. There are also terms that indicate how severe the nerve damage is.
Medicine
Naser Ghorbanian; Mahmood Eidi
Abstract
Introduction: Pharmacological interventions, such as gabapentin, have been utilized to alleviate the symptoms of CTS, but the optimal dosage remains uncertain. This article aims to review and compare the efficacy of two different doses of gabapentin, 100 mg and 300 mg, in the treatment of carpal tunnel ...
Read More
Introduction: Pharmacological interventions, such as gabapentin, have been utilized to alleviate the symptoms of CTS, but the optimal dosage remains uncertain. This article aims to review and compare the efficacy of two different doses of gabapentin, 100 mg and 300 mg, in the treatment of carpal tunnel syndrome. The findings of this review may provide valuable insights for clinicians in selecting the appropriate dosage of gabapentin, balancing the need for pain relief with the potential for adverse effects.Methodology: Following surgery, patients were administered their assigned study medication (100 mg gabapentin, 300 mg gabapentin, or placebo) orally, 1 hour before the procedure. The study medication was prepared by a pharmacist who was not involved in data collection or analysis. Both the patients and the investigators assessing the outcomes were blinded to the treatment assignment.Results: Post hoc analyses using Tukey's test were conducted to assess specific between-group differences in pain scores. At 1 hour postoperative, there was no significant difference in pain scores between the three groups (p>0.05). However, starting from 2 hours postoperative and continuing at all subsequent time points, both the 100 mg and 300 mg gabapentin groups demonstrated significantly lower pain scores compared to the placebo group (p<0.001).Conclusion: The results of this study demonstrate that both 100 mg and 300 mg doses of gabapentin are effective in reducing postoperative pain following CTS surgery. The 300 mg dose exhibited superior analgesic efficacy compared to the 100 mg dose, as evidenced by significantly lower pain scores and reduced rescue analgesia consumption.
Medicine
Vahid Fattahi; Mohammad Irajian
Abstract
The term arthroplasty refers to joint replacement through open surgery, which is used for cases where the joint has lost its function and the patient no longer has the ability to perform daily activities in the joint. In patients with knee osteoarthritis (arthrosis), the concentration of hyaluronic acid ...
Read More
The term arthroplasty refers to joint replacement through open surgery, which is used for cases where the joint has lost its function and the patient no longer has the ability to perform daily activities in the joint. In patients with knee osteoarthritis (arthrosis), the concentration of hyaluronic acid in the synovial fluid is lower than the normal value. As a result, by injecting hyaluronic acid (viscosupplementation), the patient's knee pain is reduced and the patient can carry out his daily activities as before. The pain reduction effect of hyaluronic acid injection usually lasts for 3 to 9 months, and after this period, the injection can be repeated up to 2 times. At this time, the surgeon can replace the joint by considering the patient's physical conditions as well as his age and activities. Joint replacement or arthroplasty is one of the methods considered to treat patients with advanced arthritis. Complications after arthroplasty are things that can be reduced by specialized physiotherapy. Many patients will gain appropriate abilities after surgery and recovery in physiotherapy clinics in such a way that they will return to normal conditions in daily activities, but some of them may need to extend the sessions or at least reduce the pain after surgery in different ways. The useful life of the joints depends on their conditions and how their use is different in different people and mainly the joints that bear more weight or those joints that are used more are more exposed to joint damage and destruction such as arthritis. Also, diseases such as rheumatic diseases, metabolic disorders can lead to the destruction of joints and the need for joint replacement. Most of the involved joints include hip and knee, and the incidence of involvement of these two joints is much higher than other joints.
Medicine
Mohammad Irajian; Vahid Fattahi
Abstract
Introduction: Most patients experience moderate to severe pain after ankle surgery. Early and appropriate treatment of postoperative pain is essential for effective treatment that leads to preservation of lung function, normal breathing, rehabilitation and prevention of chronic pain. In this retrospective ...
Read More
Introduction: Most patients experience moderate to severe pain after ankle surgery. Early and appropriate treatment of postoperative pain is essential for effective treatment that leads to preservation of lung function, normal breathing, rehabilitation and prevention of chronic pain. In this retrospective study, we aimed to identify potential predictors of moderate-to-severe postoperative pain in the post-anesthesia care unit (PACU) in patients undergoing gastric bypass surgery.Material and Methods: In this systematic review VAS/vNRS score of 4-6 is considered moderate, and 7-10 is considered severe. Additional factors investigated included time from ankle fracture to surgery, anesthesia procedure, preoperative anesthesia, medication use and postoperative medication use, classification radiation, bone complexity, surgical technique, and tourniquet operative time.Results: Data from 336 patients who underwent ankle arthroplasty between January 2009 and December 2022 were analyzed. None of the following variables had a significant effect on pain; age, weight, smoking, time from fracture to surgery, type of anesthesia, opioids to control dysfunction, complexity of the fracture, surgical procedure or tourniquet technique increase. Gender predicted moderate to severe pain after PACU by 2 differences.31 (1.39–3.86, P = 0.001). To our knowledge, this is the first study to report gender differences in pain reporting in the hours following joint surgery.Conclusion: Female patients who had surgery for ankle sprains reported higher pain scores in the PACU than men.
