Covid
Parham Maroufi; Tala Pourlak
Abstract
Introduction: Determining pre-operative platelet levels and their potential correlation with intraoperative bleeding is an important area of investigation in tibia fracture surgery. Platelet parameters, including platelet count, MPV, PDW, and PCT, have shown promise as potential predictors of bleeding ...
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Introduction: Determining pre-operative platelet levels and their potential correlation with intraoperative bleeding is an important area of investigation in tibia fracture surgery. Platelet parameters, including platelet count, MPV, PDW, and PCT, have shown promise as potential predictors of bleeding tendencies during surgery. By considering these parameters and other relevant clinical factors, healthcare professionals can enhance surgical planning, optimize patient care, and improve outcomes in tibia fracture surgery.Material and Methods: Pre-operative platelet levels were determined by collecting a venous blood sample from each participant within 24 hours before surgery. The blood samples were collected using standard aseptic techniques and transferred to the hospital laboratory for analysis. Platelet counts were measured using an automated hematology analyzer, which provided accurate and reliable results. During tibia fracture surgery, the amount of bleeding was measured and recorded. The surgical team employed standard techniques for intraoperative blood loss measurement, including the use of suction devices and weighing surgical sponges.Results: The results revealed a significant positive correlation between platelet count and intraoperative bleeding (p < 0.05), indicating that higher platelet counts were associated with increased amounts of bleeding during tibia fracture surgery. However, no significant correlations were observed between MPV, PDW, PCT, and intraoperative bleeding (p > 0.05).Conclusion: this study provides evidence of a significant positive correlation between pre-operative platelet count and the amount of bleeding during tibia fracture surgery. Higher platelet counts were associated with increased amounts of bleeding, suggesting that platelet count may serve as a valuable predictor of bleeding tendencies in this surgical population.
Medicine
Amin Moradi; Naghi Abedini
Abstract
Introduction: Our study compared the effectiveness of tranexamic acid in patients undergoing TKA using the three different administration methods—IV, IA, and combined IV and IA—in terms of total blood loss and the rate of allogeneic transfusion. We also wanted to compare the frequency of ...
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Introduction: Our study compared the effectiveness of tranexamic acid in patients undergoing TKA using the three different administration methods—IV, IA, and combined IV and IA—in terms of total blood loss and the rate of allogeneic transfusion. We also wanted to compare the frequency of wound complications and venous thromboembolism (VTE) among these regimens.Material and Methods: 66 TKA patients were divided into four groups based on the route of tranexamic acid administration: IV only, IA only, low-dose combined (IV + IA injection of 1 g), and high-dose combined (IV + IA injection of 2 g). This research involved 66 patients who underwent TKA between March 2019 and March 2020. Comparing the groups revealed differences in the estimated total blood loss, allogeneic transfusion rate, hemoglobin loss, frequency of symptomatic deep vein thrombosis and pulmonary embolism, wound complications, and periprosthetic joint infection.Results: There were no differences between the other three groups, but the combined high and low dose group and the IA only group lost less blood overall than the IV only group did. None of the study groups' patients received an allogeneic transfusion. There were no other symptomatic VTE events in any group, with the exception of one patient in the IV-only group who developed a symptomatic pulmonary embolism.Conclusion: Regardless of whether it is combined with IV administration, IA tranexamic acid administration further reduces blood loss after unilateral TKA compared to IV use alone. With respect to further reducing blood loss in comparison to IA alone, this study did not find any additional effects of IV combination.
Medicine
Mohammad Irajian; Vahid Fattahi
Abstract
Knee arthroplasty is a type of surgery that replaces the joint surface of the femur and leg bones in the knee joint with an artificial surface. Tranexamic acid binds to the binding sites of lysine in plasmin and plasminogen and thereby displaces plasminogen from the surface of fibrin and thus inhibits ...
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Knee arthroplasty is a type of surgery that replaces the joint surface of the femur and leg bones in the knee joint with an artificial surface. Tranexamic acid binds to the binding sites of lysine in plasmin and plasminogen and thereby displaces plasminogen from the surface of fibrin and thus inhibits fibrinolysis. Local use of tranexamic acid can reduce bleeding in gynecological and obstetric surgeries, especially after delivery, urological surgery, oral surgery in hemophilia patients, and brain and spinal cord surgeries. Tranexamic acid is a plasminogen inhibitor and also inhibits urokinase activators. Tranexamic acid can be used orally and intravenously. Urokinase is a physiological thrombolytic agent that is produced in the kidney parenchymal cells and found in the urine. Urokinase binds directly to plasminogen and produces plasmin. Tranexamic acid is a synthetic derivative of the amino acid lysine and an antifibrinolytic agent that binds to plasminogen and prevents the interaction of plasminogen with fibrin and prevents fibrin clot dissolution. Urine and urothelium contain high concentrations of plasminogen activators. Tranexamic acid is used to reduce bleeding in heart surgeries, liver transplants, orthopedic surgeries, as well as in cases of arthroplasty and knee joint replacement, and to reduce bleeding after prostatectomy or tooth extraction. Also, this drug is used to treat idiopathic menorrhagia (20-23). Although prostate surgery is a very common surgery, little study was done on strategies to reduce the amount of transfusion, and there is still no universally accepted method.
