Eurasian Journal of Chemical, Medicinal and Petroleum Research

Abstract Introduction: Lumpectomy is a standard breast-conserving procedure, yet acute postoperative complications may delay recovery and adjuvant treatment. Beyond clinical risk factors, tumor biology may influence wound healing and inflammatory responses. This study aimed to evaluate the association between progesterone receptor expression and the incidence of acute postoperative complications following lumpectomy.

Material and methods: This descriptive cross-sectional study was conducted at Tabriz University of Medical Sciences in 2025 on 54 women undergoing lumpectomy, with sample size estimated using the Cochran formula and participants enrolled by convenience sampling. Progesterone receptor expression was assessed by immunohistochemistry on surgical specimens, and its association with acute postoperative complications was analyzed alongside demographic, clinical, pathological, and perioperative variables using appropriate statistical tests.

Results: Results summary: Among 54 patients undergoing lumpectomy, PR-negative status was associated with poorer early postoperative outcomes. Compared with PR-positive patients, PR-negative patients had higher postoperative VAS scores (4.06 ± 1.43 vs. 3.14 ± 1.21; p = 0.017), more acute complications (50.00% vs. 22.22%; p = 0.037), and more unplanned visits (33.33% vs. 11.11%; p = 0.048). PR negativity independently predicted complications after adjustment (OR = 3.84; p = 0.039).

Conclusion: PR-negative status was associated with a higher risk of acute postoperative complications after lumpectomy. Despite broadly comparable operative variables, PR-negative patients experienced greater postoperative morbidity and more unplanned visits, suggesting that receptor status may help identify patients requiring closer early postoperative monitoring.

Abstract Objectives: Globalization has led to increasingly diverse patient populations in healthcare settings. Emergency departments (EDs), as high-pressure, fast-paced environments, require staff to possess strong communication and social interaction skills to ensure quality care. This study aimed to investigate the relationship between cultural intelligence (CQ) and the communication skills and social interactions of ED staff members.

Methods: This cross-sectional study conducted on 197 ED staff members from three hospitals in Zanjan, Iran, in 2019. Data collected using the Cultural Intelligence Scale (CQS), a Communication Skills Scale, and a Social Interactions Questionnaire. Data analysis performed using descriptive statistics and correlation tests.

Results: Participants' mean scores for cultural intelligence and communication skills were 85.78 ± 6.24 (out of 140) and 55.41 ± 3.9 (out of 90), respectively. For social interactions, the mean score for positive thoughts (47.86 ± 4.14) was higher than for negative thoughts (33.01 ± 3.92). The total CQ score showed a significant positive correlation with communication skills (P < 0.001). Furthermore, higher CQ scores were significantly associated with increased positive thoughts and decreased negative thoughts (P < 0.001).

Conclusions: The findings demonstrate that higher cultural intelligence among ED staff is associated with better communication skills and positive social interactions. Healthcare leaders recommended to educational programs and workshops to enhance the cultural intelligence of ED personnel, which can improve both staff communication and the quality of patient care.

Abstract Introduction: Chronic post-mastectomy pain is a common and disabling survivorship problem, and growing evidence suggests that early postoperative inflammation may contribute to its development. C-reactive protein is an accessible biomarker of surgical inflammatory response. This study aimed to evaluate whether first-postoperative-day C-reactive protein levels are associated with subsequent chronic post-mastectomy pain.

Material and methods: This descriptive cross-sectional study was conducted at Tabriz University of Medical Sciences in 2022 on 50 women undergoing mastectomy, selected by convenience sampling. Sample size was estimated using the Cochran single-group formula. The main variables included first-postoperative-day serum C-reactive protein level and chronic post-mastectomy pain at follow-up, alongside demographic, clinical, surgical, oncologic, and postoperative variables potentially related to pain development.

Results: Among 50 women undergoing mastectomy, 19 (38.0%) developed chronic post-mastectomy pain. Mean first-postoperative-day CRP was significantly higher in patients with chronic pain than in those without pain (36.2 ± 11.6 vs 23.9 ± 8.7 mg/L, P < 0.001). Axillary lymph node dissection (84.2% vs 54.8%, P = 0.034), longer operative time (127.9 ± 25.1 vs 109.8 ± 21.6 minutes, P = 0.011), and early postoperative complications (36.8% vs 12.9%, P = 0.046) were also associated with pain development.

Conclusion: Elevated first-postoperative-day CRP was independently associated with chronic post-mastectomy pain, suggesting that an intensified early postoperative inflammatory response may play an important role in pain chronification after breast cancer surgery.

Abstract Introduction: Right ventricular pacing is critical for managing bradyarrhythmia but can impair left ventricular function due to dyssynchrony. This study examines the impact of septal versus apical pacing on left ventricular ejection fraction (LVEF) using three-dimensional echocardiography, aiming to determine which approach better preserves cardiac function by maintaining more physiologic ventricular activation.

Material and methods: This randomized historical control study included 60 patients undergoing permanent pacemaker implantation at Shahid Madani Hospital between 2011 and 2013. Patients were assigned to septal or apical right ventricular pacing. Three dimensional echocardiography was used to compare left ventricular volumes and ejection fraction, with blinded assessment and standard statistical analyses to evaluate functional differences between pacing strategies.

Results: Patients with septal right ventricular pacing demonstrated preserved conventional and three‑dimensional ejection fraction with no significant deviation from normal values (P > 0.05). Compared with apical pacing, septal pacing was associated with significantly higher conventional and 3D ejection fraction and less impaired septal longitudinal strain, with a clear intergroup difference in SPSS‑Sep.A (P = 0.001).

Conclusion: This study demonstrates that right ventricular septal pacing is associated with more favorable left ventricular systolic performance compared with apical pacing when assessed using both conventional and three dimensional echocardiography.

Abstract Introduction: Breast density is a critical factor in mammography, influencing both cancer risk and detection accuracy. This study aims to determine the prevalence of various breast composition types in screening mammography and examine associations with parity and breastfeeding history among patients at Tabriz University of Medical Sciences.

Methods: This cross-sectional study included 350 women who underwent screening mammography. Breast composition was categorized into four types (A, B, C, D), and data on parity and breastfeeding were collected. Statistical analyses evaluated the associations between breast density types and reproductive factors, using a significance threshold of p < 0.05.

Results: The most frequent breast density types were Type B (44%) and Type C (43.4%), followed by Types A (4.6%) and D (8%). Higher density (Type C) was more common in nulliparous women (50%), but the association was not statistically significant (p = 0.061). Breast density was significantly higher among women who had not breastfed, with a p-value of 0.028.

Conclusion: This study suggests a significant association between breastfeeding history and lower breast density, highlighting breastfeeding’s potential impact on breast tissue composition and possibly reducing cancer risk. Although parity did not show a statistically significant relationship with breast density, reproductive history should be considered in mammographic screening and risk assessment.

Abstract This study reviews management accounting systems (MAS) in hospitals and investigates their impact on optimizing pharmaceutical costs. Given the increasing pressure on healthcare institutions to control rising costs while maintaining high standards of care, understanding the role of MAS in managing drug-related expenses is crucial. The research examines how various accounting systems, including activity-based costing (ABC) and standard costing, are implemented in hospitals to track and allocate pharmaceutical expenditures efficiently. The analysis highlights the influence of these systems on decision-making processes related to drug procurement, inventory management, and the prescription practices of medical staff. Furthermore, the study explores how the optimization of pharmaceutical costs through effective MAS contributes to overall hospital financial sustainability and better resource utilization. The findings suggest that hospitals with robust management accounting systems are more likely to optimize drug-related costs, ultimately enhancing both economic and clinical outcomes.

Key terms: Management accounting systems, Pharmaceutical costs, Activity-based costing, Healthcare finance.