Introduction: Chemotherapy is one of the most effective treatments for all types of cancer. But like other treatments, it often causes side effects. Using strong chemical drugs to stop the growth of cancer cells can also affect healthy cells and cause problems for the patient. Some side effects are short-lived and others may have long-term effects. The side effects of chemotherapy can be different for each person and it depends on the type of cancer, its location, drugs and their dosage, and the general health status of the patient. Methods: In total, 35 articles with a time limit of the last 5 years were obtained by deleting 9 articles whose full text Not available; finally, 26 articles were included in the study. Results: The side effects that chemotherapy drugs may cause in the body depend on the drug composition and the severity of the body's reaction to the drug. The side effects of chemotherapy drugs are temporary and transient, and the patient does not suffer from all side effects. Therefore, mentioning the complications is only for the purpose of knowing them better and knowing the appropriate solution to deal with it. Conclusion: Many side effects of chemotherapy can be minimized by timely diagnosis, correct adjustment of drug dosage and preventive measures. It is also necessary to improve the level of awareness of the patient and his family regarding the complications caused by the need for chemotherapy in order to help manage the complications.