Determination of ficolin-2 levels and its relationship with age in patients with osteoarthritis(OA)

Maroufi, Parham; Pourlak, Tala

doi:EJCMPR.20240306

Determination of ficolin-2 levels and its relationship with age in patients with osteoarthritis(OA)

Document Type : Original Article

Authors

Parham Maroufi ¹

Tala Pourlak ²

¹ Associated Professor of Orthopaedics, Department of Orthopedics, School of Medicine, Shohada Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

² Associate Professor of Pathology, Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

https://doi.org/EJCMPR.20240306

Abstract

Introduction: this study aims to investigate the levels of ficolin-2 in patients with OA and explore its relationship with age. By elucidating the potential role of ficolin-2 in OA pathophysiology and its association with age-related changes, this study may contribute to our understanding of the inflammatory mechanisms underlying OA.

Material and Methods: Ficolin-2 levels were quantified using a dedicated human ficolin-2 enzyme-linked immunosorbent assay (ELISA) kit. The assay followed the manufacturer's instructions with duplicate measurements for each sample. Standard curves were generated using known concentrations of ficolin-2, and sample concentrations were interpolated accordingly.

Results: Ficolin-2 levels were measured in each participant, revealing a distribution that varied across different age groups. The analysis suggested a [22/63/15] correlation between ficolin-2 levels and age.

Conclusion: this study has provided valuable insights into the relationship between ficolin-2 levels and age in patients with osteoarthritis. The positive correlation observed suggests a potential role for ficolin-2 in the age-related immune responses associated with osteoarthritis.

Keywords

ficolin-2

Osteoarthritis

relationship

age

Subjects