In many industrial applications, the presence of selectable catalysts in terms of molecular shape and size is of particular importance. The most significant feature of metal-organic structures, which has made their application important in the catalytic discussion, is the absence of dead space that cannot be accessed. Also, in such regular structures, the active sites are well separated from each other, and on the other hand, the very high surface area of these structures provide the possibility of having a high density of active sites per unit volume of the catalyst. Organometallic compounds are materials that have at least one carbon-metal bond in their structure and contain pseudo metals such as B, As, Si and real metals. Organic compounds are widely used in industry and environment. They play a role as cleaners and catalysts in industrial processes and are used in the environment because of their compatibility with it. Characterization was done in a similar way for new catalysts. The characterization tests showed that the presence of oxygen-donating ligands in the structure of manganese catalyst increases the specific surface area, dispersion of manganese particles and abundance of oxygen holes and decreases the level of crystallinity. The maximum catalytic activity was related to 12Mn-BTCarg/Al5,0.4 calcined in argon atmosphere. The activity of the optimal catalysts of each part was investigated in the activation of hydrogen peroxide to remove the drug azithromycin in aqueous solution. The catalytic elimination reaction of azithromycin followed a pseudo-first-order kinetic model. For V-DETA-MIL-101 catalyst, the amount of 15 mg of catalyst, 1.12 mmol of tertiobutyl hydrogen peroxide and 1 ml of carbon tetrachloride solvent at 80℃ temperature were selected as optimal conditions.