Chemistry
Elahe Dolati; Jalal Nourmohammadi; Hediyeh Mesbahi
Abstract
Introduction: Chemotherapy is one of the most effective treatments for all types of cancer. But like other treatments, it often causes side effects. Using strong chemical drugs to stop the growth of cancer cells can also affect healthy cells and cause problems for the patient. Some side effects are short-lived ...
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Introduction: Chemotherapy is one of the most effective treatments for all types of cancer. But like other treatments, it often causes side effects. Using strong chemical drugs to stop the growth of cancer cells can also affect healthy cells and cause problems for the patient. Some side effects are short-lived and others may have long-term effects. The side effects of chemotherapy can be different for each person and it depends on the type of cancer, its location, drugs and their dosage, and the general health status of the patient. Methods: In total, 35 articles with a time limit of the last 5 years were obtained by deleting 9 articles whose full text Not available; finally, 26 articles were included in the study. Results: The side effects that chemotherapy drugs may cause in the body depend on the drug composition and the severity of the body's reaction to the drug. The side effects of chemotherapy drugs are temporary and transient, and the patient does not suffer from all side effects. Therefore, mentioning the complications is only for the purpose of knowing them better and knowing the appropriate solution to deal with it. Conclusion: Many side effects of chemotherapy can be minimized by timely diagnosis, correct adjustment of drug dosage and preventive measures. It is also necessary to improve the level of awareness of the patient and his family regarding the complications caused by the need for chemotherapy in order to help manage the complications.
Medicine
Ali Sharifi; Zhale Bakhtiari
Abstract
Introduction: A comprehensive understanding of these complications, their risk factors, and appropriate management strategies is essential for surgeons and healthcare providers involved in the care of patients undergoing pancreaticoduodenectomy. Continued research, advancements in surgical techniques, ...
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Introduction: A comprehensive understanding of these complications, their risk factors, and appropriate management strategies is essential for surgeons and healthcare providers involved in the care of patients undergoing pancreaticoduodenectomy. Continued research, advancements in surgical techniques, and multidisciplinary collaboration are needed to further improve outcomes and reduce the incidence of complications following this challenging surgical procedure.Material and Methods: This article was a retrospective observational study conducted to evaluate the incidence, clinical significance, and management of complications associated with pancreaticoduodenectomy. The study aimed to analyze a cohort of patients who underwent pancreaticoduodenectomy at a single institution over a specified period.Results: Several factors were found to be associated with the occurrence of complications following pancreaticoduodenectomy. Prolonged operative time (>6 hours) was significantly associated with an increased risk of pancreatic fistula (p=0.043) and postoperative hemorrhage (p=0.018). Intraoperative blood loss (>500 mL) was also associated with a higher incidence of postoperative hemorrhage (p=0.032). Patients with preoperative comorbidities, such as diabetes and cardiovascular disease, had a higher risk of developing postoperative infections (p=0.016 and p=0.023, respectively).Conclusion: Complications following pancreaticoduodenectomy remain a significant challenge despite advancements in surgical techniques and perioperative care. Pancreatic fistula, delayed gastric emptying, postoperative hemorrhage, and biliary complications are among the most common complications observed in this study.
