Relationship of CC49 with Outcomes after Colorectal Cancer Surgery

Rassam, Mehrnoosh; Davoudi, Bahram

Relationship of CC49 with Outcomes after Colorectal Cancer Surgery

Document Type : Original Article

Authors

Mehrnoosh Rassam ¹

Bahram Davoudi ²

¹ General Surgeon residence, Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

² Medical Doctor, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.

Abstract

The relationship between the expression of CC49, a tumor-associated glycoprotein, and outcomes following colorectal cancer surgery has garnered significant interest in recent years. This study aims to elucidate the prognostic value of CC49 in patients undergoing surgical resection for colorectal cancer. A cohort of 300 patients was evaluated for CC49 expression through immunohistochemical analysis of tumor samples collected during surgery. The results indicated that high CC49 expression was significantly correlated with poorer overall survival and increased recurrence rates. Multivariate analysis confirmed CC49 as an independent predictor of adverse outcomes, even after adjusting for traditional risk factors such as tumor stage, lymph node involvement, and patient comorbidities. Additionally, patients with elevated CC49 levels showed a reduced response to adjuvant chemotherapy. These findings suggest that CC49 could serve as a valuable biomarker for identifying high-risk patients who may benefit from more aggressive post-surgical management and tailored therapeutic strategies. Further research is warranted to explore the underlying mechanisms by which CC49 influences tumor behavior and to validate these results in larger, prospective studies.

Keywords

Colorectal Cancer

CC49

Cancer

Surgery

Subjects