Do Adiponectin and Nesfatin Levels Predict Polycystic Ovary Syndrome (PCOS)? An Update Systematic Review

Seyedsalehi, Atefeh Sadat; Rasouli, Fakhreddin

doi:EJCMPR/20240026

Do Adiponectin and Nesfatin Levels Predict Polycystic Ovary Syndrome (PCOS)? An Update Systematic Review

Document Type : Review Article

Authors

Atefeh Sadat Seyedsalehi ¹

Fakhreddin Rasouli ²

¹ 1Department of Midwifery, Faculty of Nursing and Midwifery, Islamic Azad University, Tehran, Iran

² Medical Doctor, Medicine Faculty, Urmia University of Medical Science, Urmia, Iran

https://doi.org/EJCMPR/20240026

Abstract

Background: Contradictory findings regarding plasma levels of adiponectin and nesfatin-1 in patients with polycystic ovary syndrome (PCOS) have caused confusion among researchers. this update systematic review aimed to investigate the serum levels of adiponectin and nesfatin-1 in PCOS patients.

Materials & Methods: We systematically searched PubMed, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and SID (an Iranian database) to identify relevant studies. In accordance with the PRISMA steps, the following keywords and their combinations were used: Adiponectin, Nesfatin-1, and PCOS.

Results: A total of 28 high-quality articles were identified, of which 23 were related to adiponectin (Four reported no significant association and 19 reported a negative and significant association with PCOS) and 5 articles were related to Nesfatin-1 (4 reported a negative and significant association and one reported no association).

Conclusion: This study demonstrated that levels of adiponectin and nesfatin-1 hormones may be appropriate predictors of PCOS.

Keywords

Adiponectin

Fertility

PCOS

Nesfatin-1

Subjects