A Systematic Review: The Relation Between Vitamin D and Short Chain Fatty Acid in Serum Plasma with Protein Recombination in VDR in Multiple Sclerosis Patients (MS)

Jafari, Mehrshad; Mirzaei, Kamran Hadavand; Shojaei, Melika; Saboury, Mahdy

A Systematic Review: The Relation Between Vitamin D and Short Chain Fatty Acid in Serum Plasma with Protein Recombination in VDR in Multiple Sclerosis Patients (MS)

Document Type : Review Article

Authors

Mehrshad Jafari ¹

Kamran Hadavand Mirzaei ²

Melika Shojaei ³

Mahdy Saboury ⁴

¹ Phd Student of Cell Biochemistry and Metabolism, Bachelor of Anesthesiology and Special Care, Tehran, Iran

² General Surgeon, Laparoscopy Bariatric Surgery, Tehran, Iran

³ MD, Endocrinology & metabolism subspecialist, Iran

⁴ Assistant professor of plastic and Reconstructive Surgery, Iran

Abstract

Introduction: Vitamin D can play an important role in regulating the body's immune system, and recent studies have suggested a relationship between vitamin D serum levels and autoimmune diseases, including rheumatoid arthritis. The present study is a systematic review regarding the relationship between vitamin D and short chain fatty acid in serum plasma with protein recombination in VDR in patients with multiple sclerosis (MS).

Methodology: Several epidemiological, immunological, and genetic studies have reported the association between low vitamin D levels, measured as low blood 25-hydroxyvitamin D levels, and pre- and post-disease MS. Therefore, people with MS were screened for vitamin D deficiency, and vitamin D supplements were given along with immunomodulatory therapy. It is unclear whether vitamin D supplementation improves relevant clinical outcomes (recurrence, worsening of disability) or reduces the number of lesions seen on magnetic resonance imaging (MRI).

Conclusion: It seems that the use of vitamin D supplements in people with MS has no effect on relevant clinical outcomes or new lesions observed on MRI. Vitamin D supplementation appears to be safe at the doses and durations used in the trials, although available data are limited. Seven trials are ongoing; They will likely provide more evidence for future updates to this review.

Keywords

Vitamin D

Immune System

Vitamin Supplements

Serum Plasma

Subjects