Covid
Seyed Vahid Seyed Hosseini
Abstract
Breast cancer surgery plays a critical role in the management of breast cancer and is aimed at improving survival rates. Evidence-based guidelines have been developed to provide standardized recommendations for surgical interventions in breast cancer patients. These guidelines encompass various aspects ...
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Breast cancer surgery plays a critical role in the management of breast cancer and is aimed at improving survival rates. Evidence-based guidelines have been developed to provide standardized recommendations for surgical interventions in breast cancer patients. These guidelines encompass various aspects of breast cancer surgery, including the selection of appropriate surgical procedures, achievement of clear surgical margins, timing of surgery, and the importance of multidisciplinary collaboration. The guidelines emphasize the importance of achieving clear surgical margins, which is associated with a decreased risk of local recurrence and improved survival rates. Breast-conserving surgery, such as lumpectomy, is recommended in eligible patients to achieve tumor removal while preserving the breast. Mastectomy, the complete removal of breast tissue, may be necessary in certain cases, and the guidelines provide recommendations for patient selection and optimal timing. Sentinel lymph node biopsy is an integral part of breast cancer surgery for accurate staging and determining appropriate adjuvant therapies. The guidelines highlight the importance of multidisciplinary collaboration to ensure comprehensive evaluation, treatment planning, and follow-up care. Adherence to these guidelines, along with the integration of systemic therapies, such as chemotherapy and hormonal therapy, has shown to improve survival rates in breast cancer patients. Ongoing research and advancements in surgical techniques and molecular profiling continue to refine these guidelines, further enhancing the effectiveness of breast cancer surgery and overall patient survival rates. By following these evidence-based guidelines, healthcare professionals can optimize patient care and contribute to increased survival rates in breast cancer patients.
Medicine
Mehrnoosh Rassam; Abbasali Dehghani; Ramin Azhough
Abstract
Introduction: In the subsequent sections of this article, we will delve into the specific methodologies employed in video-assisted pilonidal sinus surgery with minimally invasive hook circulators, review existing literature on postoperative pain outcomes, and discuss the implications of these findings ...
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Introduction: In the subsequent sections of this article, we will delve into the specific methodologies employed in video-assisted pilonidal sinus surgery with minimally invasive hook circulators, review existing literature on postoperative pain outcomes, and discuss the implications of these findings for the future of pilonidal sinus disease management.Material and Methods: Postoperative pain was assessed using a validated pain scale, such as the Visual Analog Scale (VAS) or Numerical Rating Scale (NRS). Pain scores were recorded at predefined intervals post-surgery, including immediately upon awakening, at discharge, and during follow-up visits on days 1, 3, 7, and 14.Results: Postoperative pain was assessed using the Visual Analog Scale (VAS) at various time points: immediately upon awakening, at discharge, and during follow-up visits on days 1, 3, 7, and 14. The pain scores were consistently low across all time points, indicating minimal postoperative pain. This trend suggests effective pain management associated with the use of minimally invasive hook circulators.Conclusion: the study's results support the favorable impact of minimally invasive hook circulators on postoperative pain outcomes in pilonidal sinus surgery. The reduced pain scores, minimal analgesic requirements, and improved recovery trajectories underscore the potential benefits of incorporating these techniques into clinical practice.
Medicine
Mahboubeh Pazoki; Pegah Joghataie; Omolbanin Asadi Ghadikolaei; Sina Shojaei; Marjan Hajahmadi; Mohsen Taghavi Shavazi
Abstract
Objective: Cardiac thromboses are not uncommon, but right atrial thromboses are extremely rare. Methods: This study is a systematic study. 1541 articles were analyzed based on keywords and according to pubmed, scopus, web of science and embase databases. After removing duplicates, 964 articles remained. ...
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Objective: Cardiac thromboses are not uncommon, but right atrial thromboses are extremely rare. Methods: This study is a systematic study. 1541 articles were analyzed based on keywords and according to pubmed, scopus, web of science and embase databases. After removing duplicates, 964 articles remained. Finally, after reviewing the articles according to the title and abstract, 906 articles were removed and only 58 articles were included in the study and analyzed. Results: After the investigations, the results showed that in the studies, surgical treatments and anticoagulation and thrombolysis treatments were used to treat patients. Discussion: Finally, according to the data obtained from this study, it has been shown that the use of anticoagulation and thrombolysis treatment methods compared to surgical treatment for the treatment of patients can be associated with fewer complications for them. The use of surgery as the first treatment option can be combined with the use of antibiotics to prevent infection in patients. Therefore, the type of treatment can be chosen based on the clinical process and clinical symptoms of the patients.
Medicine
Ramin Azhough; Mahsa Teimoury
Abstract
Introduction: Our study examined the predictive value of six miRNAs of interest for evaluating treatment with FOLFOX and FOLFIRI when used as a first-line therapeutic option in managing patients with metastatic colorectal cancer in this context and considering the importance of this first-line treatment ...
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Introduction: Our study examined the predictive value of six miRNAs of interest for evaluating treatment with FOLFOX and FOLFIRI when used as a first-line therapeutic option in managing patients with metastatic colorectal cancer in this context and considering the importance of this first-line treatment option in managing patients with metastatic CRC.Material and Methods: We select a combination of endogenous and exogenous control miRNAs to improve the accuracy of the exosomal miRNA expression because there is currently no widely accepted best practice for exosomal miRNA normalization. Recent evidence suggests that using the same type of RNA species (miRNAs) as normalizers may be a more accurate approach than using other RNA species, such as RNU6B small nuclear RNA (U6). Due to this, we include cel-miR-39 as a spike-in (2 108 transcripts) as an exogenous normalizer and miR-16-5p as an endogen normalizer based on prior research on exosomal miRNA normalization.Results: We examined the expression of these microRNAs in 17 patients under the FOLFIRI (FIRI) protocol and 14 patients under the FOLFOX (FOX) protocol at 2 different time points (baseline and post-chemotherapy) to determine the associations between the miRNAs of interest and the response to first-line chemotherapy. At baseline (B) and post-chemotherapy (PC), there were no statistically significant differences in microRNA expression between the two chemotherapy protocols.Conclusion: Our findings demonstrated the discriminatory power of exosomal miR-92a-3p, miR-146a-5p, miR-221-3p, and miR-484 for non-responder patients regardless of the treatment employed. High baseline levels of these genes were associated with a lack of response to FOLFOX chemotherapy. Increased exosomal levels of miR-143-3p and miR-221-3p at the start of therapy have a predictive value for shorter OS, whereas increased exosomal levels of miR-92a-3p and miR-486-5p are associated with lower OS and PFS1.
Medicine
Khosro Kolahdouzan; Behrooz Nazari
Abstract
Ankle arthroplasty and total ankle arthroplasty are two important treatments for end-stage degenerative ball. Its results on the biomechanics of the medial foot are not sufficient to determine which is better. This study compared the biomechanical parameters of feet treated with ankle arthrodesis, feet ...
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Ankle arthroplasty and total ankle arthroplasty are two important treatments for end-stage degenerative ball. Its results on the biomechanics of the medial foot are not sufficient to determine which is better. This study compared the biomechanical parameters of feet treated with ankle arthrodesis, feet treated with total ankle arthroplasty, and healthy feet using statistical analysis. A validated tripod finite element model was designed to simulate the stance phase of gait. The results showed that total ankle arthroplasty provides more stable plantar pressure distribution than ankle arthrodesis. Among all replacements, the mean scaphoid joint had the highest contact pressure of 3.17 MPa. Surgery does not result in deep subscalar fusion. In both surgical models, an increase was achieved in the maximum metatarsals, especially in the second and third metatarsals. This study allows us to look at the internal biomechanics of foot defects and feet treated with total ankle arthroplasty and ankle arthrodesis during walking.
Medicine
Khosrow Hashemzadeh; Marjan Dehdilan
Abstract
Introduction: Cardiovascular care has become an important part of the continuity of care for cardiac patients. Its use is recommended in today's cardiac diagnostic procedures. Despite well-documented morbidity and mortality outcomes, cardiac services are underutilized. The basic principles of cardiac ...
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Introduction: Cardiovascular care has become an important part of the continuity of care for cardiac patients. Its use is recommended in today's cardiac diagnostic procedures. Despite well-documented morbidity and mortality outcomes, cardiac services are underutilized. The basic principles of cardiac therapy are explained in detail. Improvements in cardiac referrals, recording, and completion are possible using new performance measures. Material and Methods: Most guidelines recommend moderate-intensity exercise (60 to 75% of your maximum heart rate based on your target heart rate or ideal heart rate) for at least 30 minutes a day, at least 5 days a week, and preferably every day. Borg aerobic exercise, such as brisk walking, should be supplemented with daily water sports (such as walking after work, gardening, and housework). Results: Regular physical activity has been shown to have many cardiovascular benefits, including weight loss, lowering blood pressure, controlling diabetes and improving blood lipids. An analysis of 11 rehabilitation studies involving 115 patients found that regular physical activity was associated with a 28% reduction in all-cause mortality (6.2% vs. 9.0%) with a difference of 0.72, 95% CI 0.54–0.95)), there was a 24% reduction in myocardial infarction recurrence, but this was not significant (hazard ratio 0.76, 95% CI 0.57–1). Conclusion: Cardiovascular therapy has been shown to be safe and effective in improving quality of life and reducing morbidity and mortality in cardiac patients. Despite proven benefits, it is still not used in the treatment of heart disease. More patients will benefit from effective technology by improving referral and participation in cardiovascular care programs and personalized services involving the patient's condition.
Health
Ali Alahgholi; Ramesh Baradaran Bagheri
Abstract
Introduction: This review aimed to describe pregnancy-related hand and wrist issues and provide an overview of the pathology, clinic presentations, clinical examinations, and treatment options for these conditions; however, it does not discuss autoimmune-related musculoskeletal disorders during pregnancy. ...
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Introduction: This review aimed to describe pregnancy-related hand and wrist issues and provide an overview of the pathology, clinic presentations, clinical examinations, and treatment options for these conditions; however, it does not discuss autoimmune-related musculoskeletal disorders during pregnancy. Material and Methods: Using the terms " Hand," " Wrist," " Hand and Wrist," " Hand and Wrist problem " "pregnancy-related Hand pain," "pregnancy-related Wrist pain," and "pregnancy-related Hand and Wrist pain," we searched the literature in Pubmed, Cochrane Library, Ovid, and Google for articles in English, Portuguese, and Spanish published in the previous 20 years or older, as appropriate. Results: The quality of life for pregnant women who have hand and wrist issues may be reduced. These ailments are temporary, benign, and self-limiting, and it is anticipated that they will go away after giving birth. Conclusion: During the third trimester of pregnancy, when hormonal changes, fluid retention, and weight gain are at their peak, hand and wrist problems are most common. Although NA, pyogenic granuloma in the hand, ligamentous laxity of the joints, arthralgia, and exacerbation of arthritis in the hand and wrist have all been reported, the most common disorders are pregnancy-related CTS and De Quervain disease. For problems with the hands and wrists caused by pregnancy, non-surgical treatments are frequently successful.
