Medicine
Reza Eghdam Zamiri; Farshad Mahdavi
Abstract
Introduction: More than 400 colorectal tissues, including colorectal adenomas and cancers, and a panel of six CRC cell lines were used to study the epigenetic regulation of miR-137. Material and Methods: We go over miR-137's epigenetic control and how it affects the development of colorectal cancer. ...
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Introduction: More than 400 colorectal tissues, including colorectal adenomas and cancers, and a panel of six CRC cell lines were used to study the epigenetic regulation of miR-137. Material and Methods: We go over miR-137's epigenetic control and how it affects the development of colorectal cancer. Six CRC cell lines, 50 colorectal tissues, 21 healthy individuals' normal colonic mucosa (N-N), 160 primary CRC tissues, and their corresponding normal mucosa (N-C), as well as 68 adenomas, were used to determine the methylation status of the miR-137 CpG island. We examined the expression of miR-137 using TaqMan RT-PCR and in situ hybridization. Results: MiR-137 was only expressed in colonic epithelial cells, which cover the entire colonic crypt, in normal colonic mucosa. However, none of the adenomatous and CRC samples exhibited miR-137 expression, supporting our finding that miR-137 is silenced in the majority of colonic neoplastic tissues. As a result of our discovery that CpG island methylation causes miR-137 to be epigenetically silenced in CRC, we then carried out functional studies to see if miR-137 had tumor-suppressive properties in vitro after transfecting CRC cell lines with miR-137 precursor. Conclusion: In conclusion, this study first explains that miR-137 acts as a tumor suppressor in the colon, is frequently silenced in CRC through promoter hypermethylation, and its restoration inhibits cell proliferation in vitro.
Medicine
Abdolreza Mehdinavaz Aghdam; Fariborz Rousta
Abstract
Introduction: The objective of the study was to assess and compare the analgesic effectiveness and safety profiles of pethidine in relieving pain experienced post major surgical procedures. Material And Methods: A prospective interventional investigation was carried out on a cohort of 71 patients who ...
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Introduction: The objective of the study was to assess and compare the analgesic effectiveness and safety profiles of pethidine in relieving pain experienced post major surgical procedures. Material And Methods: A prospective interventional investigation was carried out on a cohort of 71 patients who underwent a significant surgical procedure. In this study, a total of 71 patients were administered intramuscular medication for a duration of 48 hours following surgery. Specifically, 36 individuals were treated with placebo dosages of 3 CC administered at 6-hour intervals, whereas the remaining 35 received 100 mg doses of pethidine at the same frequency. The present study aimed to evaluate and compare the analgesic efficiency and safety of placebo and pethidine. The aforementioned evaluation was performed at various time intervals of 1, 6, 12-, 24-, 32-, and 48-hours post-administration of the respective drugs. The efficacy of analgesics was evaluated through the utilization of both the Visual Analogue Scale (VAS) and Verbal Rating Scale (VRS). Results: The present study demonstrated the equianalgesic efficacy between placebo and Pethidine as determined by both Visual Analogue Scale (VAS) scores at 12 and 48 hours, and Verbal Rating Scale (VRS) scores at 1 and 48 hours during the postoperative period. During alternative observation periods, it was observed that pethidine demonstrated superior analgesic properties when compared to ketorolac. Conclusion: Pethidine demonstrated a higher degree of efficacy as an analgesic agent in comparison to ketorolac. Additional investigations, comprising a double-blind randomized trial, have been proposed to authenticate the findings presented in the current undertaking.
Medicine
Khosrow Hashemzadeh; Marjan Dehdilan
Abstract
Introduction: Our primary aim was to examine postoperative complications in cardiac surgery patients and their relationship to the use of cardiopulmonary resuscitation (CPB). A secondary aim was to evaluate the association of postoperative complications with outcome measures. Material and Methods: Single-institution ...
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Introduction: Our primary aim was to examine postoperative complications in cardiac surgery patients and their relationship to the use of cardiopulmonary resuscitation (CPB). A secondary aim was to evaluate the association of postoperative complications with outcome measures. Material and Methods: Single-institution observational study of consecutive cardiac surgery patients over 1 year. Five cardiac cases and 15 extracardiac cases were studied. CPB use, CPB parameters, demographics and Risk Adjusted Classification of Congenital Cardiac Surgery (RACHS-1) levels were evaluated as complication risk factors. Outcomes examined included duration of mechanical ventilation, length of stay in pediatric hospital, length of stay, and mortality. Results: Logistic regression analysis, after adjusting for age, sex, prior sternotomy, and RACHS-1 level, provided insufficient evidence for an association between CPB support and the incidence of cardiovascular or extracardiac problems. For patients receiving CPB, longer duration of CPB, higher RACHS-1 levels, and lower CPB temperature were associated with more cardiovascular events (P < .01). Longer CPB duration and higher RACHS-1 levels were associated with more cardiovascular complications (P = .006). Postoperative complications were associated with longer ventilator time, longer pediatric heart failure hospital stay, longer hospital stay, and death (P < .01). Conclusion: Postoperative complications occurred in 43% of pediatric cardiac procedures with and without CPB. Complications include longer use of ventilators, pediatric heart failure and hospital stay, and increased mortality.
Medicine
Marjan Dehdilan; Khosrow Hashemzadeh
Abstract
Introduction: To evaluate the outcomes of phase I cardiac treatment of stress in hospitalized patients undergoing coronary artery bypass grafting (CABG).Material and Methods: 19 patients were assigned to (1) the phase I cardiac therapy (experimental) group and (2) the no intervention group (comparison). ...
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Introduction: To evaluate the outcomes of phase I cardiac treatment of stress in hospitalized patients undergoing coronary artery bypass grafting (CABG).Material and Methods: 19 patients were assigned to (1) the phase I cardiac therapy (experimental) group and (2) the no intervention group (comparison). Finally, 60 subjects were included in the data analysis.Psychological status was measured by anxiety scores on the State-Trait Anxiety Inventory. Anxiety scores were measured over 3 sessions: (1) after admission and before CABG surgery; (2) the day before CABG surgery; (3) release date. Interventions: Self-direction of exercise and daily activities as the first stage of cardiovascular therapy (Chinese handbook) during hospitalization. Data analysis was performed using estimation equations (GEE) to evaluate the inter- and intra-group differences.Results: The average stress level of all subjects before CABG surgery was 42.6. The mean stress level of the day before CABG surgery was 33.7 in the experimental group and 49.8 in the control group; there is a difference between the two groups with a significance level of P < .05. The mean stress of the experimental group on the day of discharge was 28.6, the control group was 38.4; there is a difference between the two groups with a significance level of P < .05.Conclusion: These results are supported by similar studies. This finding suggests that phase I cardiac therapy may reduce anxiety during hospitalization in patients who have undergone CABG surgery.
Medicine
Mohammad Irajian; Vahid Fattahi
Abstract
Knee arthroplasty is a type of surgery that replaces the joint surface of the femur and leg bones in the knee joint with an artificial surface. Tranexamic acid binds to the binding sites of lysine in plasmin and plasminogen and thereby displaces plasminogen from the surface of fibrin and thus inhibits ...
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Knee arthroplasty is a type of surgery that replaces the joint surface of the femur and leg bones in the knee joint with an artificial surface. Tranexamic acid binds to the binding sites of lysine in plasmin and plasminogen and thereby displaces plasminogen from the surface of fibrin and thus inhibits fibrinolysis. Local use of tranexamic acid can reduce bleeding in gynecological and obstetric surgeries, especially after delivery, urological surgery, oral surgery in hemophilia patients, and brain and spinal cord surgeries. Tranexamic acid is a plasminogen inhibitor and also inhibits urokinase activators. Tranexamic acid can be used orally and intravenously. Urokinase is a physiological thrombolytic agent that is produced in the kidney parenchymal cells and found in the urine. Urokinase binds directly to plasminogen and produces plasmin. Tranexamic acid is a synthetic derivative of the amino acid lysine and an antifibrinolytic agent that binds to plasminogen and prevents the interaction of plasminogen with fibrin and prevents fibrin clot dissolution. Urine and urothelium contain high concentrations of plasminogen activators. Tranexamic acid is used to reduce bleeding in heart surgeries, liver transplants, orthopedic surgeries, as well as in cases of arthroplasty and knee joint replacement, and to reduce bleeding after prostatectomy or tooth extraction. Also, this drug is used to treat idiopathic menorrhagia (20-23). Although prostate surgery is a very common surgery, little study was done on strategies to reduce the amount of transfusion, and there is still no universally accepted method.
Medicine
Ebrahim Ghaibi; Mohammad Reza Soltani Manesh; Mohammad Bushra; Zohreh Gilani; Khadijeh Salimi Nabi; Farzaneh Zarif
Abstract
The purpose of this study was to compare organizational citizenship behavior and job creativity between male and female education personnel in Ahvaz District; the statistical population of this study included all the statistical population of all male and female education of Ahwaz District, with about ...
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The purpose of this study was to compare organizational citizenship behavior and job creativity between male and female education personnel in Ahvaz District; the statistical population of this study included all the statistical population of all male and female education of Ahwaz District, with about 5 people. The sample of this study consists of 5 male and female educators in Ahwaz District 2, which was used to choose from class sampling and in terms of Morgan's table. The selected method of this type of research is a comparison of the post -event type. The tools used in this study were the Questionnaire of Citizen Citizenship Behavior and Randip Creativity Questionnaire. The findings showed that, given the averages of the two groups, female prostl had higher organizational citizenship behavior than male nurses. Given the average temperature of the two groups, male pistols have more job creativity than female personnel.
Medicine
Ebrahim Ghaibi; Mohammad Reza Soltani Manesh; Hadis Jafari Dezfouli; Farzaneh Zarif; Zahra Jafari; Zahra Gilani
Abstract
AbstractThe purpose of the present study was to compare marital satisfaction, emotional divorce and religious commitment among nurses and staff of public hospitals in Ahvaz. The sample consisted of nine nurses and staff of public hospitals in the community who were selected by the available sampling ...
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AbstractThe purpose of the present study was to compare marital satisfaction, emotional divorce and religious commitment among nurses and staff of public hospitals in Ahvaz. The sample consisted of nine nurses and staff of public hospitals in the community who were selected by the available sampling method. The tools used in this study were Alason's Marital Satisfaction Questionnaire, Emotional Divorce of Razghi et al. and Barati's religious commitment. This research is comparative. The findings showed that employees have more marital satisfaction than nurses, given the average of the two groups. Due to the average of the two groups of nurses and public hospitals employees, they are in the same way in terms of emotional divorce. Given the average of the two groups of nurses, they have a higher religious commitment than employees.
