Eurasian Journal of Chemical, Medicinal and Petroleum Research

Abstract Abstract

Hyaluronic acid (HA) fillers are widely utilized in aesthetic dermatology for facial rejuvenation due to their safety and efficacy. However, delayed complications, although rare, may pose diagnostic and therapeutic challenges. We present a case of a 42-year-old female who developed a painful inflammatory nodule six months after receiving HA filler injections in the nasolabial fold. Initial conservative treatment with antibiotics and nonsteroidal anti-inflammatory drugs was ineffective. Definitive resolution was achieved following intralesional corticosteroid and hyaluronidase injections, which degraded the filler and reduced inflammation. Ultrasound imaging confirmed the presence of a well-defined subcutaneous lesion without systemic infection. This case underscores the importance of recognizing delayed inflammatory reactions to HA fillers and adopting appropriate stepwise management strategies. Early diagnosis and combined therapeutic approaches can improve patient outcomes and minimize morbidity associated with such rare complications.

Abstract Introduction: The importance of anesthesia management in epileptic patients lies in its direct impact on perioperative safety and neurologic outcomes. Inadequate anesthetic planning can precipitate breakthrough seizures, complicate recovery, and increase morbidity.

Material and methods: This systematic review and meta-analysis, conducted according to PRISMA guidelines, will evaluate randomized controlled trials and observational studies on anesthetic management in epileptic patients. Comprehensive database searches and standardized selection and extraction processes will be used. Outcomes include perioperative seizures and anesthetic complications. Study quality and heterogeneity will be rigorously assessed using validated tools and statistical analyses, ensuring reliable synthesis of current evidence to inform clinical anesthesia practices in this population.

Results: Based on the defined search strategy, 246 records were identified and narrowed through duplicate removal and rigorous screening to 8 studies included in the final qualitative synthesis. These studies, conducted internationally between 2014 and 2021, used varied designs and sample sizes to address perioperative seizure outcomes, anesthetic complications, recovery time, and hemodynamic stability, providing comprehensive and detailed evidence on anesthesia management in epileptic patients.

Conclusion: This systematic review demonstrates that, with careful selection of anesthetic protocols and individualized perioperative management, patients with epilepsy can undergo surgery with manageable rates of seizures and complications.

Abstract Introduction: This systematic review aims to synthesize evidence regarding medical and nursing care for patients with neurological diseases undergoing surgery, with a focus on pre- and post-operative considerations. This review underscores the need for standardized protocols that integrate medical and nursing perspectives in perioperative neurological care. While substantial progress has been made, gaps remain in consistent implementation of evidence-based practices and patient-centered approaches. Future research should focus on developing integrated care models and evaluating their effectiveness in enhancing surgical outcomes for patients with neurological diseases.

Methodology: Following PRISMA-based methodology, key areas include preoperative assessment, risk optimization, perioperative medication management, anesthetic strategies, and post-operative bundles of care such as hemodynamic control, secondary brain injury prevention, venous thromboembolism (VTE) prophylaxis, infection prevention, nutrition, pain management, early rehabilitation, and patient/family education.

Findings: Findings indicate that pre-operative considerations should prioritize accurate neurological assessment, optimization of comorbidities, psychological support, and patient education to enhance compliance and reduce anxiety. Pre-operative imaging, medication management (e.g., anticonvulsants, anticoagulants), and nutritional status evaluation were also identified as critical. Intraoperative nursing care, though less frequently studied, emphasizes the importance of hemodynamic stability, intracranial pressure monitoring, and prevention of complications such as hypoxia and infection.

Conclusion: Optimal perioperative care for neurosurgical patients requires a standardized, multidisciplinary, and nursing-centered approach. Critical elements include risk assessment, medication management, neuro-focused anesthesia and monitoring, structured post-op neurological checks, complication prevention, multimodal analgesia, nutrition/dysphagia management, early rehabilitation, and robust patient/family education. Adoption of ERAS pathways and quality monitoring can significantly improve outcomes and reduce healthcare costs.

Abstract Background: Cosmetic facial filler injections have become increasingly popular for facial rejuvenation. However, vascular complications, although rare, can lead to devastating outcomes including cerebral infarctions and permanent vision loss.

Objective: This study aimed to evaluate the incidence, clinical presentation, imaging findings, treatment, and outcomes of patients experiencing cerebral and ocular vascular events following facial filler injections.

Methods: A retrospective analysis was performed on cases referred to tertiary hospitals between 2016 and 2023 with documented cerebral or ocular vascular complications after dermal filler injections. Data regarding filler type, injection sites, time of symptom onset, neurological/ophthalmic evaluations, imaging results, treatments, and patient outcomes were collected.

Results: Among 24 identified patients (mean age 36.2 ± 9.8 years, 22 females), 18 (75%) suffered ophthalmic artery occlusion (OAO), 9 (37.5%) had ischemic cerebral infarctions, and 5 had combined manifestations. Most complications followed glabellar or nasal root injections using hyaluronic acid-based fillers. Permanent blindness occurred in 15 patients; neurological sequelae persisted in 7. Early intervention with hyaluronidase, corticosteroids, and hyperbaric oxygen therapy showed partial benefits.

Conclusion: Facial filler injections carry a small but catastrophic risk of cerebrovascular and ocular vascular occlusion. Increased awareness, anatomical knowledge, and adherence to safety protocols are essential to minimize risks.

Abstract Background: Amputation remains a significant public health challenge in low and middle-income countries where specialized burn care is limited. Acute burns particularly electrical burns, cause irreversible tissue damage necessitating amputation. This study examined cases of upper and lower limb amputation following burns at Shahid Motahari Educational and Treatment Center in Tehran during the years 2022-2023.

Methods: After ethical approval a retrospective review was conducted on 150 burn patients who underwent amputation. The data included demographic information, hospitalization details, burn characteristics, amputation level, and additional surgical interventions (escharotomy, grafting, debridement). Burn severity was classified based on total body surface area percentage and burn degree. The data were analyzed using SPSS version 26.

Results: The mean age of patients was 38.8 ± 16.6 years with 84% being male. The average length of hospital stay was 19.7 days and 91.3% were discharged routinely. All mortalities occurred in males. The predominant occupations were freelancers (39.3%) and laborers (24.7%). Acute burns accounted for 59.3% of cases with 47.3% of known causes due to electric shock. Upper limb amputations mainly involved the fingers (50%) or forearm (39.5%) while lower limb amputations predominantly affected the toes (68.4%) or below the knee (23.7%). Diabetes was significantly associated with lower limb amputation (P=0.003). Acute burns were associated with a higher rate of upper limb amputation (P=0.045). Lower limb amputation correlated with longer hospital stays (P=0.014).

Conclusion: Burn related amputation primarily affected working age men in high-risk occupations with electrical injuries being the main cause. The findings emphasize the need for targeted occupational safety interventions, improved prevention of electrical hazards and enhanced diabetes care. Multicenter studies evaluating long term functional and psychosocial outcomes are essential to optimize rehabilitation strategies and community reintegration.

Abstract BACKGROUND:

Severe burn injuries require prompt wound coverage to prevent complications such as infection, electrolyte imbalances, and organ failure. Skin grafting is a common approach, but limited donor sites pose challenges in extensive burns. The Meek technique offers high expansion capacity and is especially effective in poorly vascularized wounds. Most previous studies have been cross-sectional, with few directly comparing Meek and mesh grafts. This study aims to compare clinical outcomes of both techniques on different anatomical sites within the same patients.

METHODS:

This case-control study enrolled patients with third-degree burns admitted to St. Fatima Hospital in Tehran. Each patient received both mesh and modified Meek grafts on different body areas following surgical debridement. Key outcomes—including graft take, re-epithelialization time, hospital stay, and complications—were recorded and analyzed using SPSS. Ethical approval and informed consent were obtained.

RESULTS:

Among 20 patients with third-degree burns, the modified Meek technique showed significantly faster re-epithelialization (2.8 vs. 5.0 months, p=0.01), higher epithelialization within one month (55% vs. 15%, p=0.03), shorter operative time (p=0.036), and greater expansion ratio (p=0.04) compared to the mesh method. Graft rejection and infection rates were lower in the Meek group but not statistically significant.

CONCLUSION:

The modified Meek technique resulted in faster re-epithelialization, shorter operative time, and greater expansion compared to the mesh method. These advantages support its use as a preferred grafting option in extensive burn cases.