Eurasian Journal of Chemical, Medicinal and Petroleum Research

Abstract Genetic technologies in personalized medicine have revolutionized the management of anticoagulant therapy. Despite their vital role in preventing blood clots, these drugs pose numerous challenges in dose adjustment and side effect management due to the varying responses of patients. Genetic analysis has enabled the provision of personalized, safer, and more effective therapy by identifying genetic differences in related genes such as CYP2C9 and VKORC1. By precisely adjusting the dose, reducing side effects, accelerating the treatment process, and reducing costs, this technology not only improves the quality of life of patients but also paves the way for new standards in healthcare. However, challenges such as high costs, limited access, and privacy issues require attention and resolution. In this approach, the genome of the individual in question is compared with reference genomes, and based on the information obtained, the individual can be treated in an appropriate and specific way. In fact, the genetic nature of the individual determines the treatment strategy. One aspect of personalized medicine is the use of pharmacogenomics. In this method, a more appropriate and informed drug is provided by using and knowing the sequence of an individual's genome. In conventional medicine, drugs are often prescribed with the idea that the effect of the drug is the same for everyone, but in fact this is not the case and each person responds differently to the drug depending on the nature of their genome sequence. Therefore, various factors must be taken into account. For example, depending on these sequences, side effects, the required amount of drug, the likelihood of successful treatment, and the prognosis of the disease will all be unique to each individual.

Abstract The present study examined clinical and neurological problems and clinical tests in Alzheimer's patients specializing in Alzheimer's disease. The cause of Alzheimer's disease is the deposition of a series of proteins called amyloid and tau outside or inside brain cells, which occurs by creating plaques or knots in these cells. This begins before the onset of symptoms, and fortunately, this factor makes it possible to diagnose the disease before the onset of symptoms with special devices. Clinical and neurological problems and clinical tests in Alzheimer's patients are of great importance. Over time, with the deposition of these proteins in the brain, the level of neurotransmitters in the brain decreases sharply and various areas in the brain begin to shrink. The results showed that the first area of the brain to be affected is usually the memory area, but it is possible that the visual or speech and language areas of the brain may also be damaged over time. Another factor that increases the severity of this disease is aging, with some studies showing that the risk of developing Alzheimer's doubles for every five years after the age of 65. A family history of dementia, such as Parkinson's, down syndrome, severe brain injury, a sedentary lifestyle, hearing loss, depression, and heart problems are among the factors that increase a person's risk of developing this condition.

Abstract The field of AI ethics has become a global enterprise with a wide range of actors. However, AI ethics is not new. With new uses of AI, AI ethics has flourished beyond academia. For example, in 2021, UNESCO appointed 24 experts from around the world and launched a global online consultation on AI ethics to facilitate dialogue and exchange of views with all member states. One of the major problems that AI ethics and ethicists may face is the ambiguity of what is actually happening in AI, given that understanding what is good about an activity is itself very useful in determining its ethical issues. Despite the lack of transparency of AI in its current form, the important point is what kind of ethical issues can arise due to the use and development of this technology, which is a matter of debate and investigation. Another concern is transparency and explain ability. Many AI systems act like black boxes. The decision-making process is not transparent. This undermines trust among healthcare providers and patients and their companions. It is unacceptable in the medical field that even the designers of AI systems do not know exactly how AI reached a particular result due to the complexity of algorithms such as artificial neural networks. Because we are dealing with human lives here. The challenge of human decision-making is also raised. The use of medical automation processes can reach the point where AI judgment is pitted against human judgment. Relying on AI for diagnostic or treatment decisions raises questions about the role of humans. Although the use of processing power and big data reduces the error rate of AI results, who will be responsible if AI makes a mistake?

Abstract Recent advancements in CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology have revolutionized the field of gene therapy, particularly in the context of cancer treatment. CRISPR-Cas9, a powerful genome-editing tool, enables precise modifications to the DNA of cancer cells, offering new avenues for targeted therapy. This technology allows for the knockout of oncogenes, activation of tumor suppressor genes, and engineering of immune cells to enhance their anti-tumor activity. Additionally, CRISPR-based screens have facilitated the identification of novel therapeutic targets and resistance mechanisms in various cancer types. Despite its potential, challenges such as off-target effects, delivery efficiency, and immune responses remain significant hurdles. Recent innovations, including base editing, prime editing, and CRISPR interference (CRISPRi), are addressing these limitations, enhancing the specificity and safety of CRISPR applications. Furthermore, the integration of CRISPR with other therapeutic modalities, such as immunotherapy and chemotherapy, holds promise for synergistic effects in combating cancer. This review highlights the transformative impact of CRISPR technology on cancer gene therapy, discusses current advancements, and explores future directions to overcome existing barriers, ultimately paving the way for more effective and personalized cancer treatments.

Abstract Backgrounds: The aim of the preset study was to evaluate the effect of mindfulness interventions on psychological detachment from work.

Methods: MEDLINE (PubMed and Ovid), Web of Science and Scopus were among the international databases searched for relevant study keywords up to December 2024 for this systematic review and meta-analysis. This study included RCT studies published in English. STATA/MP. Data were analyzed using v17 software.

Results: Six studies included in present meta-analysis. The mean differences of psychological detachment scores between the mindfulness intervention before and after the intervention were 0.97 (MD = 0.97; 95% CI = [0.85–1.10]; p < 0.01; I2 = 88.59%; p<0.01).

Conclusion: two, six and eight-week mindfulness-based interventions can effectively extent improve psychological detachment.

Abstract One of these new concepts that was created with the increasing development of medical science and biological knowledge was “Regenerative Medicine”, which is referred to as the medicine of the future. It has been less than 20 years since the concept of regenerative medicine entered the medical field and has become one of the areas of interest of universities, research centers, and biotechnology and pharmaceutical companies. Regenerative medicine seeks to find new methods of preventing, diagnosing, and treating diseases, so that it can move from traditional medicine that works around the diagnosis and treatment with chemical and, to some extent, biotechnological drugs, towards individual-centered medicine and even precision medicine, for which biological products and drugs will play an important role. Despite the extensive advances in medical science, a significant number of human diseases are still incurable and only the symptoms of the disease are controlled. Therefore, regenerative medicine tries to treat these diseases definitively by using the same tools that the body naturally uses to repair damaged tissues and organs. These tools include: body cells, the material that surrounds cells in their natural habitat, and molecules that affect cells. Stem cells are one type of cell used in this field and have received special attention due to their great ability to transform into other cells and repair damaged areas. Stem cells play a major role in the development of organisms from the embryonic period and these cells can be identified in body tissues both during the embryonic period and after birth and are responsible for maintaining cellular balance in the normal state as well as during the process of repairing a tissue after disease.

Abstract The present study examined the iodine diet in patients with hyperthyroidism. Hyperthyroidism is a serious disease that occurs due to dysfunction of the thyroid gland and increased production of thyroid hormone. This disease is usually treated with ant thyroid drugs and, if necessary, surgery. However, a healthy diet can also have a positive effect on improving the health of patients and their condition. For this reason, experts usually recommend that patients with hyperthyroidism follow a diet suitable for hyperthyroidism, along with other treatment options. The amount of radioactive iodine used to control thyroid diseases can vary depending on the individual's disease, so that in some diseases the dose can be without side effects. A proper diet can take steps to eliminate substances that aggravate the symptoms of hyperthyroidism and help improve the symptoms of the disease. A major problem in the diet of people with hyperthyroidism is controlling the amount of iodine intake. In some cases, doctors believe that the presence of excessive amounts of iodine can be effective in cases of hyperthyroidism, and therefore controlling the amount of iodine in the diet can help relieve the symptoms of the disease. The results showed that hyperthyroidism can cause obvious weight loss and make it difficult to gain weight. This is because the body's metabolism increases in this disease. The obvious connection between diet and hyperthyroidism is the presence of iodine in the diet. There are many reasons for the belief that iodine can increase the likelihood of developing hyperthyroidism. On the other hand, Graves' disease has an interesting connection with gluten. Diet can be useful for minimizing the damage caused by hyperthyroidism, especially brittle bones.

Abstract Precision medicine is a model of medicine that personalizes healthcare by providing medical decisions, practices, or pharmaceutical products that are specific to each patient. In this model, diagnostic tests are often used to find the optimal treatment based on an individual’s genetic makeup. Tools used in precision medicine include molecular diagnostics and imaging. In this new study, researchers at Rutgers University applied personalized precision medicine to cancer treatment. Their analysis included the entire process of capturing PPM data, creating PPM products, and the social and economic consequences of using PPM. In the study, which was the result of work by several researchers at the university, the researchers report that PPM has the potential to revolutionize cancer treatment. Conventional approaches involve diagnosing a tumor and then using general treatment approaches such as surgery, chemotherapy, and radiation therapy. In contrast, in PPM, researchers use targeted treatment approaches that are more effective and have fewer unwanted side effects. These treatments are identified by analyzing specific tissues, gene mutations, and personal factors related to each unique case of cancer. Examples of these emerging treatments include immunotherapy, cancer vaccines, and ... In addition, these researchers have raised social issues related to precision and personalized medicine in health care and wellness. According to the researchers, before precision and personalized medicine becomes a part of standard cancer care, some challenges must be solved. These challenges include legal challenges, economic concerns, and the feasibility of using precision and personalized medicine, which is accompanied by economic, social, and individual problems. Today, precision and personalized medicine is becoming an effective and satisfactory approach, and before this therapeutic approach can be introduced into the fight against cancer, the aforementioned challenges must be overcome.